Faster-acting dry eye drops work well in Phase III studies

11 January 2024

Swiss-American eye specialist Alcon (NYSE: ALC) has announced positive top-line results from two Phase III trials evaluating the efficacy and safety of AR-15512.

The COMET-2 and COMET-3 studies are assessing the novel therapy, a TRPM8 agonist, for the signs and symptoms of dry eye disease.

Both trials met the primary efficacy endpoint, a commonly-used metric evaluating tear production, which the firm said was consistent with the proposed mechanism of action.

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