Extended-release opioid use disorder drugs 'priced beyond benefits'

4 December 2018

The worth of extended-release treatments for opioid use disorder has been questioned in analysis from the Institute for Clinical and Economic Review (ICER).

ICER’s Final Evidence Report looks at four therapies of this type and considers what benefits they deliver compared to the established treatment combination of buprenorphine/naloxone, first approved in the USA in 2002 under the brand name Suboxone.

The therapies focused on are Titan Pharmaceuticals’ (Nasdaq: TTNP) buprenorphine implant, branded as Probuphine, Alkermes’ (Nasdaq: ALKS) naltrexone injection, which has the brand name Vivitrol, as well as two extended-release buprenorphine injections, Indivior’s (LSE: INDV) Sublocade and Braeburn Pharmaceuticals’ CAM2038.

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