Cytokinetics glosses over omecamtiv mecarbil blip

16 February 2022

California’s Cytokinetics (Nasdaq: CYTK) has announced top-line results from the METEORIC-HF Phase III trial of omecamtiv mecarbil in patients with heart failure with reduced ejection fraction (HFrEF).

Shares in Cytokinetics closed 7% lower on Tuesday, when the results were announced, but following previous positive results, the company remains confident in the prospects of omecamtiv mecarbil, an investigational, selective, small molecule cardiac myosin activator that US biotech Amgen (Nasdaq: AMGN) gave up on in 2020.

"Demonstrating an improvement in exercise capacity ... has been elusive"It was compared in the METEORIC-HF study to placebo on exercise capacity as determined by cardiopulmonary exercise testing (CPET) following 20 weeks of treatment in patients with HFrEF receiving standard of care therapy.

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