Covant and Boehringer link up to create ADAR1 inhibitor for cancer patients

29 March 2023

Covant Therapeutics, a Boston, USA-based covalent drug discovery company that was incubated by Roivant Sciences (Nasdaq: ROIV), has entered into an exclusive research collaboration and worldwide licensing agreement with German family-owned pharma major Boehringer Ingelheim covering Covant’s ADAR1 program.

The companies jointly aim to develop a novel small molecule immunotherapy targeting ADAR1 to transform the lives of cancer patients.

The companies said the collaboration aims to create an ADAR1 inhibitor that could be used in combination with other immunotherapies to increase their efficacy. To date, existing immunotherapies have revolutionized cancer treatment but only work in a minority of patients. Inhibiting ADAR1 has the potential to address this challenge by transforming “cold” tumors into “hot” tumors, which have more immune cells present in the tumor micro-environment.

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