Case builds for semaglutide as weight loss option

5 June 2020

Phase IIIa data from the STEP 1 study show treatment with subcutaneous (SC) semaglutide at 2.4mg achieved a weight loss of 16.9%, compared to 2.4% with placebo, after 68 weeks.

The results complement positive data from the STEP 4 study of the GLP-1 agonist, released in May 2020, which showed an additional mean weight loss of 7.9%, after an initial run-in period. Those on placebo regained 6.9% of weight.

Marketed as Ozempic, a lower dose version of semaglutide is currently approved in diabetes and for reducing the risk of major adverse cardiovascular (CV) events in people with type 2 diabetes and established CV disease.

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