Calquence combo shows promise in Phase III trial

29 July 2024

British pharma major AstraZeneca (LSE: AZN) has announced positive interim results from the AMPLIFY Phase III trial of Calquence (acalabrutinib).

The study, which tests the BTK blocker in combination with venetoclax, with or without obinutuzumab, showed a significant improvement in progression-free survival compared to standard chemoimmunotherapy.

People in the study were treated in the first-line setting for chronic lymphocytic leukemia (CLL), an incurable form of leukemia which is the most common type in adults.

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