Bristol-Myers Squibb announces positive results from Phase III Opdivo trial
US pharmaceutical company Bristol-Myers Squibb (NYSE: BMY) has announced positive results from a Phase III study of Opdivo (nivolumab) in advanced, treatment-naive melanoma patients.
The trial, CheckMate -066, which involved 418 patients, showed that treatment with Opdivo led to a doubling of survival rate at two years compared to dacarbazine. Overall survival was shown to be 57.7% in patients on Opdivo compared to 26.7% in patients on dacarbazine.
The results, presented at the Society for Melanoma Research (SMR) 2015 International Congress in San Francisco this month, represent the longest survival follow-up from a Phase III trial of any programmed-death-1 (PD-1) immune checkpoint inhibitor.
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