Bright hopes fade for orphan drug, but Aeglea stays positive
Despite hitting its primary endpoint, results from the Phase III PEACE trial were not strong enough for investors, denting stock in Texan biotech Aeglea BioTherapeutics (Nasdaq: AGLE) on Monday.
Aeglea is developing pegzilarginase for the treatment of people with Arginase 1 deficiency (ARG1-D), a rare, debilitating and progressive disease.
Data from PEACE showed a statistically-significant reduction in plasma arginine from baseline after 24 weeks, as well as a positive trend in gross motor function.
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