Breakthrough Therapy designation for Padcev plus Keytruda combo

20 February 2020

Antibody-drug conjugate (ADC) specialist Seattle Genetics (Nasdaq: SGEN) and co-developer Astellas Pharma (TYO: 4503) have picked up a Breakthrough Therapy designation for Padcev (enfortumab vedotin-ejfv).

The designation applies to a combination therapy of Padcev, the firm’s second approved ADC, and Merck & Co’s (NYSE: MRK) blockbuster checkpoint inhibitor Keytruda (pembrolizumab) in bladder cancer.

The firms are developing the treatment for people with unresectable locally-advanced or metastatic urothelial cancer who are ineligible for first-line cisplatin-based chemo.

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