Bayer/Onyx's Nexavar disappoints as first-line advanced NSCLC therapy, failing to meet goals in Ph III study

14 June 2010

German drug major Bayer HealthCare and USA-based partner Onyx Pharmaceuticals revealed this morning that the final analysis of the Phase III NExUS (NSCLC research Experience Utilizing Sorafenib) trial evaluating Nexavar (sorafenib) tablets in patients with advanced non-squamous, non-small cell lung cancer (NSCLC) showed that the trial did not meet its primary endpoint of improving overall survival in the first-line setting.

NExUS evaluated Nexavar versus placebo in combination with two chemotherapeutic agents, gemcitabine and cisplatin. A positive secondary endpoint of progression-free survival (PFS) was observed in the trial. The safety and tolerability of the treatment triplet was as expected and did not show any new or unexpected toxicities. Data from this study are expected to be presented at an upcoming scientific meeting.

Bayer shares drop 2.4% on the news

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