AZ hit with new tralokinumab blows
Tralokinumab could have breathed its last as a candidate for asthma after AstraZeneca (LSE: AZN) announced two new trial failures.
The Anglo-Swedish pharma major and its research and development arm, MedImmune, have revealed top-line results of the Phase III STRATOS 2 and TROPOS trials of the anti-interleukin-13 (IL-13) human monoclonal antibody in severe, uncontrolled asthma.
In STRATOS 2, tralokinumab did not achieve a statistically-significant reduction in the annual asthma exacerbation rate, the primary endpoint, and elevated levels of a biomarker, fractional exhaled nitric oxide, compared to placebo.
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