Auris Medical Holding (Nasdaq: EARS), a clinical-stage company developing therapeutics in otolaryngology, has announced the extension of its collaboration with King's College London.
The collaboration with the UK university is focused on the discovery of small molecule compounds for a second-generation tinnitus treatment and will result in the selection of a lead compound for the company's AM-102 program.
Auris' AM-101 program in acute inner ear tinnitus suffered a major setback in August 2016 when its agent Keyzilen did not meet the co-primary efficacy endpoints in a Phase III trial of statistically-significant changes in tinnitus loudness and tinnitus burden, compared to placebo, wiping nearly 60% off the company's share price.
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