AstraZeneca's Zavicefta meets endpoint in Phase III trial
Anglo-Swedish drug major AstraZeneca (LSE: ANZ) has announced positive results from a Phase III trial of its combination antibiotic Zavicefta (ceftazidime-avibactam).
The REPROVE trial assessed the efficacy of Zavicefta compared to meropenem in the treatment of adult patients with hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP).
The new antibiotic met the primary objective of statistical non-inferiority compared to meropenem at the test of cure visit (day 21 from randomization). All-cause mortality rate at day 28 from randomisation was also similar in the two groups.
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