AstraZeneca's Tagrisso shows 'encouraging' results in leptomeningeal disease

6 June 2016

CHICAGO: Anglo-Swedish drugmaker AstraZeneca has released 'encouraging' early research data for Tagrisso (osimertinib) in patients with leptomeningeal (LM) disease at the American Society of Clinical Oncology (ASCO) annual meeting.

LM is a complication of epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer (NSCLC), where cancer cells spread to the cerebrospinal fluid (CSF).

The updated BLOOM Phase I data, presented at ASCO on Monday, reveals that irrespective of T790M status of patients, osimertinib led to a change in MRI signal intensity, which is indicative of a reduction in central nervous system (CNS) lesions.

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