AstraZeneca’s (LSE: AZN) shares fell as low as £51.58 in early trading, after the company released disappointing clinical data for its lung cancer drug candidate selumetinib, but recovered to £51.95 by late morning.
The Anglo-Swedish pharma major announced results from the Phase III SELECT-1 trial of the MEK 1/2 inhibitor, selumetinib, in combination with docetaxel chemotherapy as 2nd-line treatment in patients with KRAS mutation-positive (KRASm) locally-advanced or metastatic non-small cell lung cancer (NSCLC).
The results showed that the trial did not meet its primary endpoint of progression-free survival (PFS), and selumetinib did not have a significant effect on overall survival (OS). The adverse event profiles for selumetinib and docetaxel were consistent with those seen previously.
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