Positive Phase III data for Lynparza in pancreatic cancer

26 February 2019

The Phase III POLO trial of Lynparza (olaparib) has met its primary endpoint, the British drugmaker AstraZeneca (LSE: AZN) and New Jersey, USA-based Merck & Co (NYSE: MRK) have announced.

The trial compares the impact of the PARP inhibitor with placebo as a first-line maintenance monotherapy for certain people with pancreatic cancer, whose disease has not progressed on chemotherapy.

The results show a statistically-significant improvement in progression-free survival (PFS). The safety and tolerability profile of Lynparza was consistent with previous trials.

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