AstraZeneca and Incyte announce lung cancer clinical trial collaboration

11 January 2016

Anglo-Swedish pharma giant AstraZeneca (LON: AZN) will collaborate with US biopharmaceutical company Incyte (Nasdaq: INCY) in a new lung cancer clinical trial, it has been announced.

The trial will evaluate the efficacy and safety of Incyte’s Janus-associated kinase (JAK) 1 inhibitor, INCB39110, in combination with AstraZeneca’s next generation epidermal growth factor receptor (EGFR) inhibitor, Tagrisso (osimertinib).

The combination will be assessed as a second line treatment for patients with EGFR mutation-positive non-small cell lung cancer (NSCLC), who have been treated with a first generation EGFR tyrosine kinase inhibitor (TKI) and subsequently developed the T790M resistance mutation.

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