Astellas files for Japanese approval of ipragliflozin for types 2 diabetes

14 March 2013

Japanese drug major Astellas Pharma (TYO: 4503) has submitted a market authorization application for a SGLT2 inhibitor ipragliflozin (development code: ASP1941) to the Ministry of Health, Labor and Welfare in Japan seeking an approval for the indication of type 2 diabetes.

Ipragliflozin is a selective SGLT2 (sodium-glucose co-transporter 2) inhibitor discovered through research collaboration with Kotobuki Pharmaceutical. SGLTs are membrane proteins that exist on the cell surface and transfer glucose into cells. SGLT2 is a subtype of the sodium-glucose co-transporters and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys. Ipragliflozin reduces blood glucose levels by inhibiting the reuptake of glucose.

Ph II trial discontinued in USA and Europe

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