ASCO 2014: Novartis' LBH589 significantly improved PFS in patients with multiple myeloma; Zykadia shrinks tumors

2 June 2014

Swiss drug major Novartis (NOVN: VX) today presented results from a pivotal Phase III trial showing a 37% improvement in progression-free survival (PFS) when using the investigational compound LBH589 (panobinostat).

In combination with bortezomib (Johnson & Johnson's Velcade) and dexamethasone compared to treatment with the same regimen with placebo in patients with relapsed or relapsed and refractory multiple myeloma, LBH589 met the primary endpoint of the study (hazard ratio=0.63 [95% confidence interval (CI): 0.52 to 0.76]; p<0.0001).

The PANORAMA-1 (PANobinostat ORAl in Multiple MyelomA) trial results were presented in an oral session at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

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