Ascletis reorders research priorities after mid-stage stumble

8 April 2024

An FXR agonist developed by Ascletis Pharma (HKEX: 1672) has not performed well in mid-stage trials, leading the Hangzhou, China-based firm to dial down its investment in the drug.

The company has been testing ASC42 for primary biliary cholangitis (PBC), but will now stop work in this indication.

Safety and efficacy results from the NCT05190523 trial indicated the drug “did not show competitiveness to new PBC drug candidates currently in development and registrational stages,” Ascletis said in a statement.

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