Ascentage's lisaftoclax accepted for priority review in China
Ascentage Pharma (HKEX: 6855) will see its investigational BCL-2 selective inhibitor, lisaftoclax, assessed under China’s Priority Review scheme.
The oral small-molecule inhibitor, which is being evaluated in 19 clinical trials worldwide, works by selectively blocking the BCL-2 protein, which plays a critical role in cancer cells evading apoptosis.
If approved, lisaftoclax could become the first BCL-2 inhibitor developed in China and the second globally. The NDA is based on a registrational Phase II study testing the therapy in chronic lymphocytic leukemia and small lymphocytic lymphoma.
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