ASCO: 2024: Another win for KRAS blockers, including in combination therapy

3 June 2024

Eli Lilly (NYSE: LLY) has released updated data from its Phase I/II clinical trial evaluating olomorasib.

The data relate to use of the KRAS blocker both as a monotherapy for KRAS G12C-mutant advanced solid tumors and in combination with Merck & Co's (NYSE: MRK) checkpoint blocker Keytruda (pembrolizumab), for advanced non-small cell lung cancer.

There is a wave of interest in KRAS blockers, an approach which targets a mutation present in lung cancers but also certain colorectal and pancreatic cancers.

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