US drug developer ArQule (Nasdaq: ARQL) saw its shares plunge 23% to $2.25 in premarket trading on Friday, as the company, along with partner Japanese pharma major Daiichi Sankyo (TSE 4568) announced disappointing top-line results of a randomized Phase II signal generation trial of tivantinib (ARQ 197) used in combination with irinotecan and cetuximab in patients with refractory or relapsed colorectal cancer (CRC).
This is the second disappointment regarding the compound; last fall, the companies announced they were halting a Phase III study in non-small cell lung cancer (NSCLC) of tivantinib after independent monitors concluded the drug would not meet its endpoint of prolonging overall patient survival (The Pharma Letter October 3, 2012).
Missed primary endpoint of PFS
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
7 day trial access
Become a subscriber
Or £77 per month
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
Copyright © The Pharma Letter 2024 | Headless Content Management with Blaze