Annovis Bio announces positive data for buntanetap in AD

30 April 2024

USA-based neurodegenerative disorders specialist Annovis Bio (NYSE: ANVS) saw its shares plunge 60% to $7.28 by close of trading, despite what it said were positive results for its Alzheimer’s disease (AD) candidate.

The company announced the data from its Phase II/III Alzheimer study of buntanetap in mild to moderate Alzheimer’s disease patients. Based on these data, Annovis says it plans to conduct a pivotal Phase III trial in biomarker-positive early AD patients.

Buntanetap is an oral molecule that selectively binds to an iron-responsive element in the mRNA of amyloid precursor protein (APP) and other neurotoxic proteins and inhibits their translation. Through this mechanism, buntanetap was shown to decrease the production of amyloid beta (Aβ), tau, alpha-Synuclein (αSYN), and TDP43.

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