Alzheimer's treatment from China meets Phase III goal
Shanghai, China-based Green Valley Pharmaceutical today announced that its Phase III Study of sodium oligomannurarate (GV-971) capsules on mild-to-moderate Alzheimer's disease met its primary endpoint.
This randomized, double-blinded and placebo-controlled clinical trial in China aimed to evaluate safety and efficacy of GV-971, a multi-targeting oligosaccharide drug, on study participants with mild-to-moderate Alzheimer's disease (MMSE score ranged from 11 to 26). Subjects took 450mg GV-971 orally twice each day for 36 weeks. The primary endpoint showed the improved change of the Alzheimer's Disease Assessment Scale-cognitive (ADAS-cog) score after the 36 week GV-971 treatment compared to the placebo control. GV-971 showed a similar profile to that of the placebo, no amyloid-related imaging abnormalities (ARIA) were observed.
The drug opens a new avenue for treatment and provides patients with a new solution and hope, said lead researcher Geng Meiyu.
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