Allergan to move into Phase III trials with depression drug that's raising eyebrows

7 April 2017

Botox (onabotulinumtoxinA), a treatment which made its name for its aesthetic potential in reducing facial wrinkles, is to be taken into Phase III trials in major depressive disorder (MDD).

This is despite the failure of a Phase II trial of Botox in moderate to severe MDD.

Ireland-incorporated drugmaker Allergan (NYSE: AGN) announced the results of this study this week. The efficacy, safety and tolerability of a single administration of two different doses of 30 or 50 units of Botox relative to placebo in women with MDD was evaluated over 24 weeks.

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