Aduro Biotech's CRS-207 fails in pancreatic cancer immunotherapy trial
USA-based Aduro Biotech (Nasdaq: ADRO) lost almost a third of its share price on Monday after missing the primary endpoint in its trial of CRS-207, a treatment that was being evaluated alone, and alongside GVAX Pancreas, for pancreatic cancer.
The Phase IIb ECLIPSE trial did not meet the primary endpoint of an improvement in overall survival for patients with pancreatic cancer who had failed at least two prior therapies in the metastatic setting.
Median overall survival (MOS) in this third-line and greater setting was 3.8 months for people treated with the immunotherapy regimen of CRS-207 and GVAX Pancreas, 5.4 months for those given CRS-207 alone and 4.6 months for patients administered chemotherapy.
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