Adding Roche's Avastin to radio/chemotherapy extends PFS for brain cancer patients

13 August 2012

Swiss drug major Roche (ROG: SIX) announced on Friday that the Phase III AVAglio study of its blockbuster cancer drug Avastin (bevacizumab) plus radiation and temozolomide chemotherapy in people with newly diagnosed glioblastoma met its co-primary endpoint of a significant improvement in progression-free survival (PFS).

In the study, Avastin in combination with radiation and temozolomide chemotherapy significantly extended the time people with this aggressive form of primary brain cancer lived without their disease getting worse (PFS), compared to those treated with radiation and temozolomide chemotherapy plus placebo. Data for final overall survival (OS), the other co-primary endpoint, are expected in 2013.

NPV of 4.29 francs/share for added indication

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