US drugmaker AbbVie (NYSE: ABBV), in cooperation with Neurocrine Biosciences (Nasdaq: NBIX), announced positive top-line results from the second of two replicate pivotal Phase III clinical trials evaluating the efficacy and safety of elagolix in premenopausal women who suffer pain from endometriosis.
Rights to the orally administered gonadotropin-releasing hormone (GnRH) antagonist were acquired by Abbott (of which AbbVie is a spin-out) from Neurocrine in 2010, under a deal which could earn the latter as much as $575 million (The Pharma Letter June 17, 2010). Neurocrine’s shares were up 3.6% at $32.19 in pre-market trading, and rose 8.7% to $35.00 by mid-afternoon, while AbbVie’s stock was largely unchanged.
Analysts, including Deutsche Bank’s Robyn Karnauskas, have previously forecast peak sales of elagolix at a potential $1.2 billion-plus.
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