Pfizer’s Talzenna and Xtandi combo prolongs OS in mCRPC
US pharma giant Pfizer (NYSE: PFE) today released positive top line results from the final prespecified overall survival (OS) analysis of the TALAPRO-2 study of Talzenna (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with Xtandi (enzalutamide), an androgen receptor pathway inhibitor (ARPI), in patients with metastatic castration-resistant prostate cancer (mCRPC).
The results showed a statistically-significant and clinically meaningful improvement in the final OS in all-comers (cohort 1) as well as in those patients with homologous recombination repair (HRR) gene-mutated mCRPC (cohort 2), compared to Xtandi alone.
Pfizer acquired both Xtandi and Talzenna in 2016 through its $14 billion acquisition of Medivation. The combo gained European approval for mCRPC in January this year and by the US Food and Drug Administration (FDA) in June last year.
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