Partners aim to develop new class of obesity therapeutics
Abalone Bio, an antibody company measuring large-scale activity data to drive AI-powered discovery of active therapeutics, has announced a collaboration with the University of Pennsylvania, Perelman School of Medicine, to develop new antibody-based obesity drugs.
The partnership brings together UPenn’s expertise in metabolic disease research and pre-clinical screening with Abalone’s ability to discover functional antibodies that activate G-protein coupled receptors (GPCRs).
Obesity drugs such as GLP-1 receptor agonists have transformed weight management, but nearly 50% of patients discontinue treatment within a year, often due to intolerable gastrointestinal side effects.
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