Opthea’s future unclear after wet AMD failure
Australia-based Opthea (ASX/Nasdaq: OPT), a biopharma developing therapies for progressive retinal diseases, has announced results from its global Phase III trial COAST in patients with wet age-related macular degeneration (AMD).
COAST evaluated the efficacy and safety of intravitreally administered 2mg sozinibercept every four or eight weeks in combination with 2mg aflibercept (Eylea), as per label, every eight weeks after a loading phase for the treatment of wet AMD.
The trial did not meet its primary endpoint of mean change in best corrected visual acuity (BCVA) from baseline to week 52.
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