NuCana tanks as it discontinues NuTide:323 study
UK-based NuCana (Nasdaq: NCNA) saw its shares tumble almost 50% to $3.96 in after-hours trading yesterday, when it announced that the NuTide:323 study is being discontinued following a pre-planned initial analysis and recommendation from the NuTide:323 Study steering committee.
This is the second pipeline setback for NuCana, which in 2020 shuttered the NuTide:121 study based on an assessment from independent data monitors.
While there were prognostic imbalances favoring the control arm, the steering committee believed that the combination of NUC-3373 with leucovorin, irinotecan and bevacizumab (NUFIRI+bev) was unlikely to achieve the study’s primary objective of superior Progression Free Survival (PFS) compared to the control arm of 5-FU, leucovorin, irinotecan and bevacizumab (FOLFIRI+bev) in the final analysis.
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