Novo Nordisk teams up with IMMvention Therapeutix on SCD
USA-based biotech IMMvention Therapeutix yesterday revealed it has entered into a strategic collaboration and license agreement with Novo Nordisk (NOV: N) to co-develop oral therapies for sickle cell disease (SCD) and other chronic conditions.
The Danish diabetes and obesity giant, which has made several moves to broaden its therapeutic portfolio, established itself as a player in sickle cell in 2022 when it acquired Forma Therapeuticsfor $1.1 billion.
The partnership will leverage IMMvention’s investigational small-molecule BACH1 inhibitors. BACH1 is thought to be a key regulator of cellular responses, oxidative stress, and inflammation in multiple disease states, making it a promising therapeutic target. Currently in pre-clinical development, IMMvention’s orally dosed BACH1 inhibitors have the potential to increase fetal hemoglobin, which is believed to ameliorate SCD disease pathology.
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