Nimbus and Lilly achieve AMPK program milestone

25 February 2025

Boston, USA-based biotech Nimbus Therapeutics today revealed that, along with partner Eli Lilly (NYSE: LLY), it has achieved a significant pre-clinical milestone in their research collaboration targeting AMP-activated protein kinase (AMPK) for the treatment of cardiometabolic diseases.

The team has identified a highly selective isoform-specific AMPK activator – which may solve a decades-old challenge in drug development, said Nimbus.

AMPK, a key regulator of cellular energy metabolism, is a well-validated target that drug developers have been after for decades, but without clinical success. Why does Lilly believe Nimbus may succeed where others have failed?

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