NICE recommends Breyanzi for B-cell lymphomas

21 February 2025

UK health technology assessor the National Institute for Health and Care Excellence (NICE) has issued Final Draft Guidance recommending the use Breyanzi (lisocabtagene maraleucel) for National Health Service (NHS) in England.

Developed by US pharma major Bristol Myers Squibb (NYSE: BMY), Breyanzi is authorized for the treatment of adult patients with diffuse large B-cell lymphoma (DLBCL), high grade B-cell lymphoma (HGBCL), primary mediastinal large B-cell lymphoma (PMBCL) and follicular lymphoma grade 3B (FL3B), who relapsed within 12 months from completion of, or are refractory to, first-line chemoimmunotherapy, when a stem cell transplant is suitable.

The company noted that the decision follows regulatory authorization of lisocabtagene maraleucel in October 2023 by the UK Medicines and Healthcare products Regulatory Agency (MHRA).

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