NICE backs AstraZeneca’s Truqap

11 April 2025

The UK’s National Institute for Health and Care Excellence (NICE) has recommended AstraZeneca’s (LSE: AZN) Truqap (capivasertib) with fulvestrant as an option for around 1,100 adults with hormone receptor (HR)-positive HER2-negative breast cancer that has certain genetic mutations and has spread.

The final draft guidance recommends capivasertib with fulvestrant for people with hormone receptor (HR)-positive HER2-negative breast cancer that has one or more PIK3CA, AKT1 or PTEN gene alterations and has spread within the breast tissue (locally advanced) or to other parts of the body (metastatic).

In 2020 in England, 40,192 people were diagnosed with breast cancer, approximately 14.8% of who had advanced stage disease when they were diagnosed.

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