The H5N1 virus, known for its 50% human case fatality rate, has persisted globally for over two decades, causing thousands of infections.
The recent outbreaks, including those affecting US dairy cows, have accelerated the development of next-generation vaccines, with mRNA vaccines stepping into the spotlight, aiming to replicate the success achieved during the COVID-19 pandemic, says pharma analytics company GlobalData.
According to GlobalData, while the majority of the 22 vaccine candidates currently in development rely on traditional approaches, mRNA vaccines make up less than 10% of the pipeline. However, the rapid development and potential efficacy seen during the COVID-19 pandemic signal a significant shift in the H5N1 vaccine landscape.
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