Merck & Co cuts TIGIT and LAG-3 programs
US pharma giant Merck & Co (NYSE: MRK) has announced the discontinuation of the clinical development programs for vibostolimab, an anti-TIGIT antibody, and favezelimab, an anti-LAG-3 antibody.
Vibostolimab has been evaluated as an investigational fixed-dose combination with Merck’s Keytruda (pembrolizumab) in the KeyVibe program, while favezelimab has been studied in fixed-dose combination with the same drug in the KEYFORM program.
Merck is discontinuing the Phase III KeyVibe-003 and KeyVibe-007 trials of vibostolimab and Keytruda in certain patients with non-small cell lung cancer, based on the recommendation of an independent Data Monitoring Committee.
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