Merck & Co buys in oral GLP-1 RA from China’s Hansoh

18 December 2024

US pharma giant Merck & Co (NYSE: MRK) and Chinese biopharma Hansoh Pharma (03692.HK)  have entered into an exclusive global license agreement for HS-10535, an investigational pre-clinical oral small molecule GLP-1 receptor agonist (RA).

Merck joins the likes of Amgen (Nasdaq: AMGN), Pfizer (NYSE: PFE), AstraZeneca (LSE: AZN), Structure Therapeutics and Viking Therapeutics (Nasdaq: VKTX) among companies testing oral drugs for obesity in the hope they will provide patients a more convenient option than injectable options.

Under the agreement, Hansoh has granted Merck an exclusive global license to develop, manufacture and commercialize HS-10535 and will receive an upfront payment of $112 million. The company is also eligible to receive up to $1.9 billion in milestone payments associated with the development, regulatory approval and commercialization of the candidate, as well as royalties on sales. 

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