Merck & Co buoyed by Phase III results with HIV tablet
US pharma giant Merck (NYSE: MRK) has announced top-line results from two pivotal Phase III trials of the investigational, once-daily, oral, two-drug, single-tablet regimen of doravirine/islatravir (DOR/ISL).
These trials involved patients with HIV-1 infection that is virologically suppressed on different antiretroviral therapy regimens, MK-8591A-051 or bictegravir/emtricitabine/tenofovir alafenamidei (BIC/FTC/TAF).
The success criterion for the primary efficacy hypothesis, as measured by the percentage of participants with HIV-1 RNA levels ≥50 copies/mL at week 48, was met in both trials.
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