MacroGenics puts the brakes on vobra duo development

7 November 2024

Maryland-based MacroGenics, (NASDAQ: MGNX), a biopharma focused on discovering, developing, manufacturing and commercializing innovative antibody-based therapeutics for the treatment of cancer, has provided an update on its lead antibody-drug conjugate (ADC) vobramitamab duocarmazine (vobra duo).

Vobra duo targets B7-H3, an antigen with broad expression across multiple solid tumors and a member of the B7 family of molecules involved in immune regulation.

MacroGenics is developing the ADC for people with metastatic castration-resistant prostate cancer (mCRPC), as a second-line option.

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