J&J to discontinue SunRISe-2 study of TAR-200

9 October 2024

Johnson & Johnson (NYSE: JNJ) has halted the late-stage SunRISe-2 study of its bladder cancer drug candidate TAR-200, owing to unfavorable results.

The SunRISe-2 study in patients with muscle-invasive bladder cancer (MIBC) who are not receiving radical cystectomy was a bold approach to disrupt the established standard of care in chemoradiation in this difficult-to-treat population, the US healthcare giant noted.

However, following an Independent Data Monitoring Committee recommendation and pre-specified interim analysis, SunRISe-2 was discontinued for not showing superiority versus chemoradiation, said J&J.

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