J&J’s Rybrevant and Lazcluze show continued benefit over Tagrisso
Johnson & Johnson (NYSE: JNJ) has announced important overall survival (OS) results from the Phase III MARIPOSA study.
Head-to-head comparison data versus Tagrisso (osimertinib), AstraZeneca’s (LSE: AZN) standard-of-care treatment, showed that J&J’s Rybrevant (amivantamab) and Lazcluze (lazertinib) significantly extended OS in the first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletions (ex19del) or L858R substitution mutations.
Median OS is projected to exceed one year beyond the median of three years observed with Tagrisso, and has not yet been reached.
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