Isis Pharma's Positive Data With Antisense Drug
- Isis Pharmaceutical's has reported that ISIS 5132 retarded human tumor growth in animal xenografts. The drug, a selective antisense inhibitor of C-raf kinase gene expression, was intravenously administered in doses ranging from 0.06mg/kg/day to 6.0mg/kg/day and culminated in complete remission of treated animals. The compound is currently in Phase I clinical trials for the treatment of a range of solid tumors, with results anticipated at end-1996.
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