Higher dose nusinersen shows significant benefit in SMA, says Biogen

4 September 2024

US biotech major Biogen (Nasdaq: BIIB) today announced positive, top-line data from the pivotal cohort (Part B) of the Phase II/III DEVOTE study evaluating the safety and efficacy of a higher dose regimen of nusinersen in treatment-naïve, symptomatic infants with spinal muscular atrophy (SMA).

Marketed under the trade name Spinraza, nusinersen generated second-quarter 2024 sales of $429.1 million, down 2%.

The SMA market across the major markets is projected to grow from $2.7 billion in 2023 to $3 billion by 2033 by pharma analytics firm GlobalData. Apart from Biogen, other leaders in the sector include Roche’s (ROG: SIX) Evrysdi (risdiplam), and Novartis’ (NOVN: VX) Zolgensma (onasemnogene abeparvovec).

This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Try before you buy

Free

7 day trial access

Take a Free Trial

All the news that moves the needle in pharma and biotech
Exclusive features, podcasts, interviews, data analyses and commentary from our global network of life sciences reporters.
Receive The Pharma Letter daily news bulletin, free forever.

Become a subscriber

£820

Or £77 per month

Subscribe Now

Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
Daily roundup of key events in pharma and biotech.
Monthly in-depth briefings on Boardroom appointments and M&A news.
Choose from a cost-effective annual package or a flexible monthly subscription

The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK