Higher dose nusinersen shows significant benefit in SMA, says Biogen
US biotech major Biogen (Nasdaq: BIIB) today announced positive, top-line data from the pivotal cohort (Part B) of the Phase II/III DEVOTE study evaluating the safety and efficacy of a higher dose regimen of nusinersen in treatment-naïve, symptomatic infants with spinal muscular atrophy (SMA).
Marketed under the trade name Spinraza, nusinersen generated second-quarter 2024 sales of $429.1 million, down 2%.
The SMA market across the major markets is projected to grow from $2.7 billion in 2023 to $3 billion by 2033 by pharma analytics firm GlobalData. Apart from Biogen, other leaders in the sector include Roche’s (ROG: SIX) Evrysdi (risdiplam), and Novartis’ (NOVN: VX) Zolgensma (onasemnogene abeparvovec).
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