The impact of patent expires and resulting generic completion is taking a significant toll on the US sales of some leading brands, according to Drugs.com, the on-line clinical drug resource, which yesterday released second quarter 2012 US prescription sales data for the top 100 drugs.
Proton-pump inhibitors, antipsychotics, asthma therapeutics and statins remain the top-selling categories. However, Sanofi’s Plavix (clopidogrel) and AstraZeneca’s Seroquel (quetiapine) dipped in the second quarter due to loss of patent protection. Other top brands such as Merck & Co’s Singulair (montelukast sodium), Eisai’s Actos (pioglitazone) and Novartis’ Diovan valsartan) are also due to be impacted by year's end.
Top five drugs by sales, 2nd-qtr 2012
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