Efficacy and safety data show strong reduction in HIV infections with lenacapavir

8 October 2024

US antivirals specialist Gilead Sciences (Nasdaq: GILD) has released additional data from its pivotal Phase III PURPOSE 2 trial providing an overview of the efficacy and safety of twice-yearly lenacapavir, the company’s injectable HIV-1 capsid inhibitor, for the investigational use of HIV prevention among a broad and geographically diverse range of cisgender men and gender-diverse people.

The data are being presented today at the 5 th HIV Research for Prevention Conference in Lima, Peru.

The new data come after initial results in September, which showed that twice-yearly lenacapavir reduced HIV infections by 96% compared to background HIV incidence (bHIV) and demonstrated / superiority to once-daily Truvada (emtricitabine and tenofovir disoproxil fumarate) for HIV prevention as pre-exposure prophylaxis (PrEP).

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