HIV specialist ViiV Healthcare, which is majority owned by UK pharma major GSK (LSE: GSK), today announced 48-week findings from PASO DOBLE (GeSIDA 11720 study).
ViiV noted that this is the largest head-to-head, Phase IV randomized clinical trial (RCT) investigating the two- drug regimen Dovato (dolutegravir/lamivudine [DTG/[3TC]) compared to the three-drug regimen with Gilead Sciences’ (Nasdaq: GILD) blockbuster drug Biktarvy (bictegravir/emtricitabine]/tenofovir alafenamide fumarate [BIC/FTC/TAF]) for the treatment of HIV-1 in people who are virologically suppressed and who could benefit from treatment optimization.
Findings showed that switching to DTG/3TC in virologically suppressed adults living with HIV demonstrated non-inferior efficacy in maintaining viral suppression compared with switching to BIC/FTC/TAF. These data will be presented at the 25th International AIDS Conference (AIDS 2024), held in Munich, Germany (July (22-26).
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