Depression failure sends Supernus shares downwards
US CNS specialist Supernus Pharmaceuticals (Nasdaq: SUPN) has announced that its Phase IIb study of SPN-820 in adults with treatment-resistant depression (TRD) did not demonstrate a statistically significant improvement on the primary endpoint.
This study examined the efficacy and safety of SPN-820 over a course of four weeks of treatment and then a week of blinded placebo-washout in some 250 patients from around 40 clinical sites.
The change from baseline in the Montgomery-Åsberg depression rating scale total score to week four, the trial’s primary endpoint, did not reach the required significance.
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